2 edition of Kinin hormones, with special reference to bradykinin and related kinins found in the catalog.
Kinin hormones, with special reference to bradykinin and related kinins
M. Rocha e Silva
Bibliography: p. 257-298.
|Statement||by M. Rocha e Silva.|
|Series||American lecture series. Publication no. 781. A monograph in the Bannerstone division of American lectures in living chemistry|
|LC Classifications||QP552.K5 S5413|
|The Physical Object|
|Pagination||xii, 317 p.|
|Number of Pages||317|
|LC Control Number||73103585|
The kallikrein–kinin system (KKS) is an endogenous pathway involved in many biological processes. Although primarily related to blood pressure control and inflammation, its activation goes beyond these effects. Neurogenesis and neuroprotection might be stimulated by bradykinin being of . Kinins (peptides related to bradykinin, BK) are formed from circulating substrates, the kininogens, by the action of two proteases, the kallikreins. The only clinical application of a BK receptor ligand, the B2 receptor antagonist icatibant, is the treatment of the rare hereditary angioedema (HAE) caused by the deficiency of C1-esterase inhibitor (C1-INH).
autacoids act like local hormones and have a ____ effect. paracrine. 3 kinds of autacoids and examples of each. 1. Decarboxylated AA: histamine, serotonin kinins (bradykinin) Pre-kallikrein (inactive) to kallikrein is activated by. Activated by Hageman factor (HF) -tissue injury can cause local kinin . CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Kinins are vasoactive peptides released from precursors called kininogens, and serum levels of both T- and K-kininogens increase dramatically as rats age. Kinin release is tightly regulated, and here we show that serum kinin levels also increase with age, from 63 6 16 nmol/L in young Fisher rats to 6 nmol.
Rocha e Silva, Maurice, Silva, M. Rocha e (Maurício Rocha e), Silva, Maurício Rocha e, Silva, Mauricio Rocha e Rocha E Silva, Mauricio. ponents of the kallikrein–kinin cascade have been iden-tiﬁed at such sites. Neutrophils that migrate to inﬂamed sites play a pivotal role in the formation of kinins as they possess all the components of the kallikrein–kinin cascade, namely membrane bound kininogens,8,9 kinin-releasing enzyme, KLK,11 and kinin B 1 (B 1R) recep-.
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Kinin hormones, with special reference to bradykinin and related kinins. Springfield, Ill., Thomas  (OCoLC) Online version: Silva, M. Rocha e (Maurício Rocha e), Kinin hormones, with special reference to bradykinin and related kinins. Springfield, Ill., Thomas  (OCoLC) Document Type: Book: All Authors.
Kinin hormones, with special reference to bradykinin and related kinins, by M. Rocha e Silva. Format Book Published Springfield, Ill., Thomas  Description xii, p.
illus. (1 col.) 24 cm. Series American lecture series. Publication no. Marty K.S. Wong, in Handbook of Hormones, Abstract.
Kinins [bradykinin (BK) and [Lys0]-BK] are the active peptides for the kallikrein-kinin system (KKS) and they are potent endothelium-dependent vasodilators that contribute to vasodilation and hypotension in the systemic induce thirst in mammals but inhibit drinking in teleosts. Author(s): Rocha e Silva,M(Mauricio), Title(s): Kinin hormones; with special reference to bradykinin and related kinins.
Country of Publication: United States. DEFINITIONS A. Kinin Hormones. The name of kinins suggested by English authors (Hilton, ; Lewis, ) might be usefully applied to the group of tissue hormones of polypeptide nature which act on smooth muscles and either decrease or increase blood pressure in definition would exclude the neurohypophyseal hormones.
It is characteristic of this group of substances that they Cited by: 4. Other articles where Kinin is discussed: hormone: Endocrine-like glands and secretions: Blood contains kinins, which are polypeptides that originate in the blood and perhaps elsewhere; bradykinin, for example, causes contraction of most smooth muscles and has a very potent action in dilating certain blood vessels.
Its function, which is not yet established, may be to regulate the rate. The Clinical Studies of the Kallikrein-Kinin System with Special Reference to Bronchial Asthma. Release of the Antidiuretic Hormone by Bradykinin in Rats.
Book Title Bradykinin and Related Kinins Book Subtitle Cardiovascular, Biochemical, and Neural Actions. Typically, kinins are locally produced at injured or inflamed tissues sites where they act through a combined endocrine/paracrine mode. In a first step, the high-molecular weight inactive kinin precursor proteins, the kininogens, are targeted to the inflamed site where the kinins are eventually proteolytically liberated from the kininogens by specific kininogenases, the kallikreins.
A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin. They are members of the autacoid family. They act locally to induce vasodilation and contraction of smooth muscle. Kinins function as mediators for inflammatory responses by triggering the immune system.
They are also able to regulate cardiovascular and renal function through mediating the effects of. Bradykinin (Greek brady- slow; -kinin, kīn(eîn) to move) is a peptide that promotes causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries.
It has been well established in the literature (Stürmer and Be r de, ; Schröder and Lübke, ; Stewart and Woolley, ) that the pharmacological actions of bradykinin and its two known natural derivatives (Lys Bk and Met-Lys-Bk) change if we prolong the chain of amino acids, at the NH 2-terminal, according to the biological preparation utilized, as well as to their resistance to.
The constitutively active rabbit bradykinin B 2 receptor (a G i -and G q -protein coupled receptor) was cloned in 45 and is the target of endogenous kinins such as bradykinin (BK) and.
The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its.
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain.
The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease. E.K. Frey, H. Kraut, E. Werle (eds.): "Das Kallikrein-Kinin-System und seine Inhibitoren".
Ferdinand Enke Verlag, Stuttgart M. Rocha e Silva (ed.): "Kinin Hormones with Special Reference to Bradykinin and Related Kinins" Charles C. Thomas Publisher, Springfield Illinois-USA, Kinin hormones, with special reference to bradykinin and related kinins, (American lecture series.
Publication no. A monograph in the Bannerstone. of American lectures in living chemistry) M. Rocha e. A CBS News reference book on civil rights: a current guide to the people, organizations, and events.
Presented in 4 appendices, bibliography and index. Red and white covers, with black and white lettering, and a pictorial panel on the front. Kinin B1 receptors (BKB1R) are mainly expressed at sites of inflammation and therefore potentially safe drug targets for inflammatory diseases. BKB1R antagonism and gene deletion has been shown to be beneficial in numerous animal models of inflammatory diseases, with few exceptions.
Several companies have developed orally available BKB1R. Rosmarie Vogel, Gertrud Zickgraf-Rüdel, Evaluation of the Role of Kinins in Experimental, Pathological, and Clinical Conditions; the Therapeutic Use of Kallikrein Inhibitor, Bradykinin, Kallidin and Kallikrein, /, (), ().
kinin: [ ki´nin ] the generic term for any of the polypeptides related in amino acid sequence and physiological activity to bradykinin and kallidin, formed by kallikrein-mediated cleavage of kininogens.
Kinins are plasma proteins that increase vascular permeability, interact with prostaglandins to cause pain and smooth muscle contraction and.
Full Text; PDF ( K) PDF-Plus ( K) Citing articles; Kallikrein–kinin system as the dominant mechanism to counteract hyperactive renin–angiotensin system 1.
Domenico Regoli, a Fernand Gobeil b a Department of Medical Sciences, University of Ferrara, Ferrara, Italy. b Department of Pharmacology and Physiology, Université de Sherbrooke, Québec, QC J1H 5N4, Canada.Reflexogenic effects of bradykinin, lysyl-bradykinin and endogenously formed kinins on neural afferents of the left ventricular epicardium were studied in anaesthetized, open-chest dogs.
2. Epicardial application of either bradykinin ( micrograms), lysyl-bradykinin ( micrograms) or tissue kallikrein ( U) consistently.Application of Water-Insoluble Complexes of Kininogenases, Inhibitors and Kininases to Kinin Research.- Kinin Formation in Human Blood Serum Induced by Cooling and by Heat Aggregated Human Gamma Globulin Preparations.- Kinin Metabolism in Normal and Malignant Leucocytes.- Optical Activity and Conformation of Bradykinin and Related Peptides